Location: Home >> Using CRISPR-Editing to Engineer T Cell TCR Genes to Fight Cancer: A Research Proposal
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As we age, our bodies naturally become less effective at fighting cancer. One primary reason is our immune system’s decreased ability to produce new, adaptive T cells. With decreased antigen recognition capabilities, our immune system begins to succumb to immunoediting. This is the process by which tumor cells evolve to evade immunosurveillance via ongoing selection against presenting antigens that the body’s T cells recognize. To combat this issue, this proposal aims to use CRISPR-editing to create mutations in the beta-chain V regions of the T cell’s TCR gene. Because protein mutations affect the molecular structure of the TCRs, this method can also affect what antigens it is able to bind to. Creating a large population of diversely-recombinant T cells would expand the immune system’s ability to recognize new tumor antigens, stimulating a cellular immune response to generate a systemic attack on the cancer.
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Matthew Sun. Using CRISPR-Editing to Engineer T Cell TCR Genes to Fight Cancer: A Research Proposal. International Journal of Medicine Frontiers, 2023, 6(1), 25-28.
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