References

[1] Cebatariūniené A, Kriauc iūnaité K, Prunskaité J, et al. Extracellular Vesicles Suppress Basal and Lipopolysaccharide-Induced NFκB Activity in Human Periodontal Ligament Stem Cells [J]. Stem Cells Dev, 2019, 28(15):1037-1049. 

[2] Albiero ML, Amorim BR, Casati MZ, et al. Osteogenic potential of periodontal ligament stem cells are unaffected after exposure to lipopolysaccharides [J]. Braz Oral Res, 2017, 31: e17. 

[3] Professional Committee of Periodontology, Chinese Stomatological Association. Evaluation criteria of basic periodontal examination in oral diagnosis and treatment [J]. Chinese Journal of Stomatology, 2021, 56 (03):238-243. 

[4] Li L, Liu W, Wang H, et al. Mutual inhibition between HDAC9 and miR-17 regulates osteogenesis of human periodontal ligament stem cells in inflammatory conditions [J]. Cell Death Dis, 2018, 9(5):480. 

[5] Kusuyama J, Nakamura T, Ohnishi T, et al. Low-intensity pulsed ultrasound promotes bone morphogenic protein 9-induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho-associated kinase 1 in human periodontal ligament fibroblasts [J]. J Cell Biochem, 2019, 120(9):14657-14669. 

[6] Huang X, Chen H, Xie Y, et al. FoxO1 Overexpression Ameliorates TNF-α-Induced Oxidative Damage and Promotes Osteogenesis of Human Periodontal Ligament Stem Cells via Antioxidant Defense Activation [J]. Stem Cells Int, 2019, 2019: 2120453. 

[7] Yu B, Li Q, Zhou M. LPS induced upregulation of the TLR4 signaling pathway inhibits osteogenic differentiation of human periodontal ligament stem cells under inflammatory conditions [J]. Int J Mol Med, 2019, 43 (6):2341-2351. 

[8] Huang RL, Yuan Y, Zou GM, et al. LPS-stimulated inflammatory environment inhibits BMP-2-induced osteoblastic differentiation through crosstalk between TLR4/MyD88/NF-κB and BMP/Smad signaling [J]. Stem Cells Dev, 2014, 23 (3):277-289. 

[9] Zhang Z, Pan X, Chen M, et al. Wnt signalling in oral and maxillofacial diseases. Cell Biol Int, 2022, 46: 34-45. 

[10] Zhang F, Liu C L, Tong M M, et al. Both Wnt/β-catenin and ERK5 signaling pathways are involved in BDNF-induced differentiation of pluripotent stem cells into neural stem cells [J]. Neurosci Lett, 2019, 708:134345. 

[11] Maeda K, Takahashi N, Kobayashi Y. Roles of Wnt signals in bone resorption during physiological and pathological states [J]. Mol Med (Berl), 2013, 91 (1):15-23. 

[12] Nusse R, Clevers H. Wnt/β-Catenin Signaling, Disease, and E-merging Therapeutic Modalities [J]. Cell, 2017, 169 (6):985-999. 

[13] Seifert JR, Mlodzik M. Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility [J]. Nat Rev Genet, 2007, 8:126-138. 

[14] Topol L, Jiang X, and Choi H, et al. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation [J]. J Cell Biol, 2003; 162(5):899-908. 

[15] Zhang R, Yang G, Wu X, et al. Disruption of Wnt/β-catenin signaling in odontoblasts and cementoblasts arrests tooth root development in postnatal mouse teeth [J]. Int J Biol Sci. 2013, 9: 228-236. 

[16] Xiang L, Mo C, Ling H, et al. Wnt5a regulates dental follicle stem/ progenitor cells of the periodontium. Stem Cell Research & Therapy, 2014, 5: 135. 

[17] Little RD, Carulli JP, Del Mastro RG, et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait [J]. American journal of human genetics, 2002, 70(1): 11-19. 

[18] Gong Y, Slee RB, Fukai N, et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development [J]. Cell, 2001, 107(4): 513-523. 

[19] Gopinathan G, Foyle D, Luan X, et al. The Wnt antagonist SFRP1: a Key regulator of periodontal mineral homeostasis [J]. Stem Cells Dev, 2019, 28: 1004-1014. 

[20] Nanbara H, Wara-aswapati N, Nagasawa T, et al. Modulation of Wnt5a expression by periodontopathic bacteria [J]. PLoS One, 2012, 7(4): e34434. 

[21] Pereira C , Schaer DJ , Bachli EB , et al. Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10 [J]. Arterioscler Thromb Vasc Biol, 2008, 28(3): 504-510. 

[22] Lü L, Yakoumatos L, Ren J, et al. JAK3 restrains inflammatory responses and protects against periodontal disease through Wnt3a signaling [J]. FASEB J, 2020, 34: 9120-9140. 

[23] Maekawa T, Kulwattanaporn P, Hosur K, et al. Differential Expression and Roles of Secreted Frizzled-Related Protein 5 and the Wingless Homolog Wnt5a in Periodontitis [J]. J Dent Res, 2017, 96: 571-577. 

[24] Haftcheshmeh SM, Mohammadi A, Soltani A, et al. Evaluation of STAT1 and Wnt5a gene expression in gingival tissues of patients with periodontal disease [J]. J Cell Biochem, 2018, online ahead of print.